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Posted by / 03-Aug-2020 18:57

Botulinum toxins have been used off-label for several pediatric conditions, including infantile esotropia.While botulinum toxin is generally considered safe in a clinical setting, there can be serious side effects from its use.In January 2014, botulinum toxin was approved by UK's Medicines and Healthcare Products Regulatory Agency (MHRA) for treatment of restricted ankle motion due to lower limb spasticity associated with stroke in adults.On July 29, 2016, Food and Drug Administration (FDA), of the United States of America approved abobotulinumtoxin A for injection for the treatment of lower limb spasticity in pediatric patients two years of age and older.However, muscles adapt to the lengths at which they are chronically held, so that if a paralyzed muscle is stretched by its antagonist, it grows longer, while the antagonist shortens, yielding a permanent effect.

Trivalent (A, B, E) botulinum antitoxin is derived from equine sources using whole antibodies.The toxin is also used commercially in medicine, cosmetics and research.Botulinum is the most acutely lethal toxin known, with an estimated human median lethal dose (LD Botulinum toxin types A and B are used in medicine to treat various muscle spasms and diseases characterized by overactive muscle.Most commonly, botulinum toxin can be injected into the wrong muscle group or spread from the injection site, causing paralysis of unintended muscles.Side effects from cosmetic use generally result from unintended paralysis of facial muscles.

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